The Rab-interacting lysosomal protein (RILP) regulates vacuolar ATPase acting on the V1G1 subunit

نویسندگان

  • Maria De Luca
  • Laura Cogli
  • Cinzia Progida
  • Veronica Nisi
  • Roberta Pascolutti
  • Sara Sigismund
  • Pier Paolo Di Fiore
  • Cecilia Bucci
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RILP regulates vacuolar ATPase through interaction with the V1G1 subunit.

Rab-interacting lysosomal protein (RILP) is a downstream effector of the Rab7 GTPase. GTP-bound Rab7 recruits RILP to endosomal membranes and, together, they control late endocytic traffic, phagosome and autophagosome maturation and are responsible for signaling receptor degradation. We have identified, using different approaches, the V1G1 (officially known as ATP6V1G1) subunit of the vacuolar ...

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A new V-ATPase regulatory mechanism mediated by the Rab interacting lysosomal protein (RILP)

Progressive luminal acidification of intracellular compartments is important for their functions. Proton transport into the organelle's lumen is mediated by vacuolar ATPases (V-ATPases) large multi-subunit proton pumps organized into 2 domains, V0 and V1, working together as a rotary machine. The interaction of each subunit with specific partners plays a crucial role in controlling V-ATPase act...

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تاریخ انتشار 2014